Conventional flow cytometric (FCM) analyses and FCM lifetime analysis are being used to elucidate mammalian sperm chromatin structural changes in response to physiological and radiological stimuli, particularly those stimuli that lead to apoptosis. Most of the abnormal spermatogonia following irradiation appear to be undergoing apoptosis but the morphologic features are not typical, suggesting apoptosis may have different appearances in different cell types. These studies are designed to develop new methods for evaluating different modes of cell death in testis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001315-18
Application #
6327952
Study Section
Project Start
2000-07-01
Project End
2001-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
18
Fiscal Year
2000
Total Cost
$1,532
Indirect Cost
Name
Los Alamos National Lab
Department
Type
DUNS #
City
Los Alamos
State
NM
Country
United States
Zip Code
87545
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