Georgetown University is studying the mechanisms of chromosomal instability in breast cancer, in particular the amplification or mutation of several oncogenes and suppresser genes. They are focused on the role of the myc oncogene in transgenic mouse models as a model system whereby they may study its role in mammary tumorigenesis.
The specific aims are to obtain sorted mouse chromosomes from the FVB strain, fluorescently label these chromosomes to establish multicolor FISH spectral karyotyping at Georgetown, and to use this technique to establish the time dependent nature of chromosomal instability induced by the c-myc oncogene in mouse mammary epithelial cells.
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Ai, Ye; Sanders, Claire K; Marrone, Babetta L (2013) Separation of Escherichia coli bacteria from peripheral blood mononuclear cells using standing surface acoustic waves. Anal Chem 85:9126-34 |
Sanders, Claire K; Mourant, Judith R (2013) Advantages of full spectrum flow cytometry. J Biomed Opt 18:037004 |
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Vuyisich, Momchilo; Sanders, Claire K; Graves, Steven W (2012) Binding and cell intoxication studies of anthrax lethal toxin. Mol Biol Rep 39:5897-903 |
Chaudhary, Anu; Ganguly, Kumkum; Cabantous, Stephanie et al. (2012) The Brucella TIR-like protein TcpB interacts with the death domain of MyD88. Biochem Biophys Res Commun 417:299-304 |
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