A form of two-dimensional (2D) vibrational spectroscopy was used to examine the structure of a cyclic penta-peptide (cyclo-Mamb-Abu-Arg-Gly-Asp) for which both the NMR and the x-ray structures are known. Spectrally resolved cross peaks occur in the off-diagonal region of the 2D IR spectrum, analogous to those of 2D NMR of proteins and peptides. The first results have been published (Proc. Natl. Acad. Sci. USA 96, 2036 (1999)).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001348-18
Application #
6120111
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
18
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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