Dr. Ellis-Davies has developed a series of new calcium cages which use the well known ortho-nitrobenzyl photochemistry for uncaging. He wishes to characterize these compounds using flash photolysis techniques and to measure the rate of appearance of the released Ca using low affinity Ca dyes (e.g. fluo-3FF or Ca-orange-5N). He developed a new photochemical protecting groups (not based on nitrobenzyl chemistry) which will be quite fast (ca. 100 ns for uncaging). These compounds will also be tested.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001348-18
Application #
6120148
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
18
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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