This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project is to develop a composite (biodegradable polymer and nanorods) for controlled delivery of therapeutic molecules. The polymer is designed so that the glass transition temperature is ~ 5 degrees C above body temperature, so that when the sample is exposed to NIR light (~ 800 nm) and the absorbing nanorods heat, the sample goes from a glassy to rubbery polymer. It is hypothesized that this transition change will lead to changes in molecule diffusion through the polymer and will simultaneously be released to the surrounding tissue. We have conducted all conducted all work on the polymer mechanical transitions, nanorod fabrication, and the next step is to illustrate that the samples heat upon light exposure. If that is shown, the release of a molecule will be measured with exposure of the sample to light.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001348-29
Application #
8169550
Study Section
Special Emphasis Panel (ZRG1-BCMB-N (40))
Project Start
2010-06-01
Project End
2011-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
29
Fiscal Year
2010
Total Cost
$4,159
Indirect Cost
Name
University of Pennsylvania
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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