Abstract

We propose to continue and expand the National Vibrating Probe Facility. This expansion should bring the facility up to full operating capacity and allow us to best serve users throughout the country (as well as abroad). It should also allow us to develop a series of ion-specific vibrating probes and an aerial vibrating probe; to extend our measurements of endogenous ionic currents to certain plasmalemma-free preparations; to continue our collaborative exploration of possible currents through the tips of growing nerves as well as the vegetal poles of various embryos; and to continue training new users and disseminating news of our findings and capacities. The user projects should continue to focus on a wide variety of growing and developing systems as well as mature, functioning epithelia. Moreover, they should include ones of medical as well as basic biological interest, particularly in the general area of wound healing and regeneration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001395-09
Application #
3103901
Study Section
Special Emphasis Panel (SSS (D))
Project Start
1982-09-01
Project End
1991-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Marine Biological Laboratory
Department
Type
DUNS #
001933779
City
Woods Hole
State
MA
Country
United States
Zip Code
02543

  Publications

Demidenko, Eugene; Glaholt, S P; Kyker-Snowman, E et al. (2017) Single toxin dose-response models revisited. Toxicol Appl Pharmacol 314:12-23
Chowanadisai, Winyoo; Messerli, Shanta M; Miller, Daniel H et al. (2016) Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors. PLoS One 11:e0151089
De Martino, Federico; Moerel, Michelle; Ugurbil, Kamil et al. (2015) Less noise, more activation: Multiband acquisition schemes for auditory functional MRI. Magn Reson Med 74:462-7
Van Mooy, Benjamin A S; Hmelo, Laura R; Fredricks, Helen F et al. (2014) Quantitative exploration of the contribution of settlement, growth, dispersal and grazing to the accumulation of natural marine biofilms on antifouling and fouling-release coatings. Biofouling 30:223-36
Brodsky, Alexander S; Fischer, Andrew; Miller, Daniel H et al. (2014) Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease. PLoS One 9:e94476
De Martino, Federico; Zimmermann, Jan; Muckli, Lars et al. (2013) Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE. PLoS One 8:e60514
De Martino, Federico; Moerel, Michelle; van de Moortele, Pierre-Francois et al. (2013) Spatial organization of frequency preference and selectivity in the human inferior colliculus. Nat Commun 4:1386
Vang, Souriya; Wu, Hsin-Ta; Fischer, Andrew et al. (2013) Identification of ovarian cancer metastatic miRNAs. PLoS One 8:e58226
Chowanadisai, Winyoo; Graham, David M; Keen, Carl L et al. (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A 110:9903-8
Olman, Cheryl A; Harel, Noam; Feinberg, David A et al. (2012) Layer-specific fMRI reflects different neuronal computations at different depths in human V1. PLoS One 7:e32536

Showing the most recent 10 out of 144 publications