OUR STUDIES ON THE ACIDIFICATION OF THE VAS DEFERENS FORMED ROUND THE COMMON INTEREST OF DRS. SMITH AND BROWN IN THE PHYSIOLOGICAL ROLE OF THE VACUOLAR-TYPE PROTON ATPASE. RESULTS HAVE BEEN EXTREMELY ENCOURAGING WITH PROBE DATA SUPPORTING IMMUNOHISTOCHEMICAL STUDIES IN ATTRIBUTING A MAJOR ROLE TO THESE PUMPS IN REGULATING MAMMALIAN SPERM ACTIVITY. THUS, THE V-TYPE PROTON PUMPING ATPASE IS IMPLICATED AS THE MAJOR SOURCE OF THE LUMINAL ACIDIFICATION IN PARTS OF THE MALE REPRODUCTIVE TRACT. THIS ENZYME IS LOCATED IN A MINORITY CELL TYPE, WHICH RESEMBLES THE ACID-SECRETING INTERCALATED CELL OF THE RENAL COLLECTING DUCT. FURTHER DETAILS ARE GIVEN IN HIGHLIGHTS. THIS PROJECT HAS NOW BEEN JOINED BY DR. BRETON AS POSTDOCTORAL FELLOW IN DR. BROWN~S LAB.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR001395-14S1
Application #
5223336
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
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