This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Dr. Heck is interested in mechanisms of oxidative stress induced by ultraviolet light as a mechanism of carcinogenesis. She has been characterizing endogenous cellular photosensitizers and antioxidants that form a balance in protecting cells from ultraviolet light-mediated toxicity. Dr. Heck has found that nitric oxide is a key mediator of the actions of ultraviolet light. Her research has focused on determining if nitric oxide functions as an anti-oxidant of a pro-oxidant. Towards this end she has been active in the BRC in developing and validating a nitric oxide self-referencing biosensor. In the BRC she has been characterizing nitric oxide production by a variety of cell types. She has also been investigating the role of peroxynitrite in mediating cellular oxidative stress as measured using a self-referencing oxygen biosensor. In collaboration with Joshua Gray, she has been investigating the role of hyperoxia in mediating cellular nitric oxide production.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001395-25
Application #
7598476
Study Section
Special Emphasis Panel (ZRG1-BPC-H (40))
Project Start
2006-12-01
Project End
2007-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
25
Fiscal Year
2007
Total Cost
$11,719
Indirect Cost
Name
Marine Biological Laboratory
Department
Type
DUNS #
001933779
City
Woods Hole
State
MA
Country
United States
Zip Code
02543
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