Abstract

The objective of this subproject is construction of a high resolution 3D probability rat brain atlas. This will consist of a histological dataset reconstructed into a 3D volume at a resolution of 20um/voxel. Additionally, a tensor map reflecting interanimal variability will be embedded into this atlas. With this system it will be possible to combine brain maps derived from different rats into a single multimodal representation. Not only will this greatly accelerate data analysis, but it will permit exploring the relation between the distribution of different compounds in a new and powerfult way.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001638-11
Application #
5223486
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ivey, Richard G; Subramanian, Oby; Lorentzen, Travis D et al. (2009) Antibody-based screen for ionizing radiation-dependent changes in the Mammalian proteome for use in biodosimetry. Radiat Res 171:549-61
Palha, J A; Nissanov, J; Fernandes, R et al. (2002) Thyroid hormone distribution in the mouse brain: the role of transthyretin. Neuroscience 113:837-47
Shumsky, Jed S; Wu, Yunxing; Murphy, E Hazel et al. (2002) Differential effects of prenatal cocaine exposure on selected subunit mRNAs of the GABA(A) receptor in rabbit anterior cingulate cortex. J Chem Neuroanat 24:243-55
Nissanov, J; Bertrand, L; Tretiak, O (2001) Cryosectioning distortion reduction using tape support. Microsc Res Tech 53:239-40
Komisaruk, B R; Rosenblatt, J S; Barona, M L et al. (2000) Combined c-fos and 14C-2-deoxyglucose method to differentiate site-specific excitation from disinhibition: analysis of maternal behavior in the rat. Brain Res 859:262-72
Del Cerro, M C (1998) Role of the vomeronasal input in maternal behavior. Psychoneuroendocrinology 23:905-26
Cohen, F S; Yang, Z; Huang, Z et al. (1998) Automatic matching of homologous histological sections. IEEE Trans Biomed Eng 45:642-9
Ali, W S; Cohen, F S (1998) Registering coronal histological 2-D sections of a rat brain with coronal sections of a 3-D brain atlas using geometric curve invariants and B-spline representation. IEEE Trans Med Imaging 17:957-66
Shumsky, J S; Wu, Y; Murphy, E H et al. (1998) Prenatal cocaine exposure does not affect selected GABAA receptor subunit mRNA expression in rabbit visual cortex. Ann N Y Acad Sci 846:371-4
Libon, D J; Bogdanoff, B; Cloud, B S et al. (1998) Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer's disease and ischaemic vascular dementia. J Clin Exp Neuropsychol 20:30-41

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