Abstract

The main thrust of the research conducted by the Crozer-Chester Medical Center (CCMC) neuropsychology service is to investigate the cognitive and neuropsychological differences between patients with a variety of dementing disorders, such as Alzheimer's disease, ischaemic vascular dementia, and Parkinson's disease. Although the issue of differential diagnosis is certainly an important factor in this research, the primary goal is to investigate the cognitive neuropsychological differences between these patient groups. On the basis of Dr. Libon's neuropsychological research, various patient groups have been dissociated on the basis of their performance of tests of motor functioning, frontal lobe functioning, semantic knowledge, visuoconstruction, declarative memory, and procedural memory. The collaborative work being undertaken with Drexel seeks to develop quantitative indices derived from MRI scans of the brain obtained from patients and relate this information directly to the clinical and neuropsychological information that is also obtained on all patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001638-11
Application #
5223498
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ivey, Richard G; Subramanian, Oby; Lorentzen, Travis D et al. (2009) Antibody-based screen for ionizing radiation-dependent changes in the Mammalian proteome for use in biodosimetry. Radiat Res 171:549-61
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Shumsky, Jed S; Wu, Yunxing; Murphy, E Hazel et al. (2002) Differential effects of prenatal cocaine exposure on selected subunit mRNAs of the GABA(A) receptor in rabbit anterior cingulate cortex. J Chem Neuroanat 24:243-55
Nissanov, J; Bertrand, L; Tretiak, O (2001) Cryosectioning distortion reduction using tape support. Microsc Res Tech 53:239-40
Komisaruk, B R; Rosenblatt, J S; Barona, M L et al. (2000) Combined c-fos and 14C-2-deoxyglucose method to differentiate site-specific excitation from disinhibition: analysis of maternal behavior in the rat. Brain Res 859:262-72
Ali, W S; Cohen, F S (1998) Registering coronal histological 2-D sections of a rat brain with coronal sections of a 3-D brain atlas using geometric curve invariants and B-spline representation. IEEE Trans Med Imaging 17:957-66
Shumsky, J S; Wu, Y; Murphy, E H et al. (1998) Prenatal cocaine exposure does not affect selected GABAA receptor subunit mRNA expression in rabbit visual cortex. Ann N Y Acad Sci 846:371-4
Libon, D J; Bogdanoff, B; Cloud, B S et al. (1998) Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer's disease and ischaemic vascular dementia. J Clin Exp Neuropsychol 20:30-41
Del Cerro, M C (1998) Role of the vomeronasal input in maternal behavior. Psychoneuroendocrinology 23:905-26
Cohen, F S; Yang, Z; Huang, Z et al. (1998) Automatic matching of homologous histological sections. IEEE Trans Biomed Eng 45:642-9

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