Application of spectral analysis to heart rate data collected from infants with intrauterine exposure to cocaine and normal controls showed a significant sleep state effect on HRV, with greater high frequency power seen during quiet sleep (QS) compared to active sleep (AS) and greater low- and mid-frequency power seen in AS compared to QS. However, in both sleep states, the cocaine-exposed neonates showed enhanced total spectral power that appears to be due to an increase in spectral power across all frequency bands. Absolute values for spectral power in the low- and mid-frequency bands of HRV were significantly higher in the cocaine-exposed group in both sleep states. The absolute value for high frequency power was also higher, but this increase attained statistical significance only in quiet sleep. We found no evidence for respiratory patterning differences between the two groups that might account for these findings. Very little of the total respiratory variability in QS and AS was in the low-to-mid-frequency range, suggesting that periodic breathing contributed little to HRV in that same frequency range. We also computed the fractional distribution of heart rate variation across all frequencies as a means of examining sympathovagal balance. Ratios between low- and mid-frequency power compared to high frequency power showed no differences between the groups, although there was a highly significant increase in AS compared to QS. The present results suggest two possibilities: (1) an increase in parasympathetic control of heart rate in the cocaine-exposed infants; or (2) an increase in both vagal and sympathetic modulation of heart rate in the cocaine-exposed group.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Song, Dong; Wang, Haonan; Tu, Catherine Y et al. (2013) Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions. J Comput Neurosci 35:335-57
Hoppenbrouwers, Toke; Oliveira, Flavia; Sandarupa, Stanislaus et al. (2012) The development of the circadian heart rate rhythm (CHR) in Asian infants. Early Hum Dev 88:555-61
Wang, Xiaoning; Schumitzky, Alan; D'Argenio, David Z (2007) Nonlinear Random Effects Mixture Models: Maximum Likelihood Estimation via the EM Algorithm. Comput Stat Data Anal 51:6614-6623
Gholmieh, Ghassan; Courellis, Spiros; Marmarelis, Vasilis et al. (2007) Nonlinear dynamic model of CA1 short-term plasticity using random impulse train stimulation. Ann Biomed Eng 35:847-57
Gholmieh, Ghassan; Courellis, Spiros; Dimoka, Angelika et al. (2004) An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings. J Neurosci Methods 136:111-21
Ashjian, Peter; Elbarbary, Amir; Zuk, Patricia et al. (2004) Noninvasive in situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy. Tissue Eng 10:411-20
Blasi, Anna; Jo, Javier; Valladares, Edwin et al. (2003) Cardiovascular variability after arousal from sleep: time-varying spectral analysis. J Appl Physiol 95:1394-404
Jo, Javier A; Blasi, Anna; Valladares, Edwin et al. (2003) Model-based assessment of autonomic control in obstructive sleep apnea syndrome during sleep. Am J Respir Crit Care Med 167:128-36
Belozeroff, Vasily; Berry, Richard B; Khoo, Michael C K (2003) Model-based assessment of autonomic control in obstructive sleep apnea syndrome. Sleep 26:65-73
Bading, James R; Yoo, Paul B; Fissekis, John D et al. (2003) Kinetic modeling of 5-fluorouracil anabolism in colorectal adenocarcinoma: a positron emission tomography study in rats. Cancer Res 63:3667-74

Showing the most recent 10 out of 84 publications