The importance of the vestibulo-ocular reflex (VOR) for stabilizing vision during active movements is generally unrecognized, until pathology impairs VOR performance sufficiently to interfere with dynamic visual acuity. We have developed VOR modeling techniques that allow clinicians to evaluate patients VOR function objectively. During the past year, we extended these modeling techniques to include objective monitoring during therapy. We introduced a new measure of """"""""super performance"""""""" based on athletes' abilities to improve their dynamic visual acuity through exercise therapy. By modeling their VORs during therapy, we are able to monitor and predict improvements in dynamic visual acuity during athletic performance. Mild head injury during sports performance often shows up as decreased visual stabilization by the VOR. Two professional football tams are currently being tested with our modeling techniques. In addition, the University of Virginia conducted a study of 100 athletes, using our VOR modeling techniques. A doctoral thesis in Exercise Physiology at that university is based on re-testing the VORs of a subset of these athletes after mild head injury. We extended our analysis of the broad-band characteristics of the VOR to studies of human subjects during walking/running. The preliminary results describe an important new role for lower-frequency channels of the VOR, that we anticipate will lead to focused therapy for preventing falls in the elderly.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001861-16
Application #
6339178
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
2000
Total Cost
$143,160
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Song, Dong; Wang, Haonan; Tu, Catherine Y et al. (2013) Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions. J Comput Neurosci 35:335-57
Hoppenbrouwers, Toke; Oliveira, Flavia; Sandarupa, Stanislaus et al. (2012) The development of the circadian heart rate rhythm (CHR) in Asian infants. Early Hum Dev 88:555-61
Wang, Xiaoning; Schumitzky, Alan; D'Argenio, David Z (2007) Nonlinear Random Effects Mixture Models: Maximum Likelihood Estimation via the EM Algorithm. Comput Stat Data Anal 51:6614-6623
Gholmieh, Ghassan; Courellis, Spiros; Marmarelis, Vasilis et al. (2007) Nonlinear dynamic model of CA1 short-term plasticity using random impulse train stimulation. Ann Biomed Eng 35:847-57
Gholmieh, Ghassan; Courellis, Spiros; Dimoka, Angelika et al. (2004) An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings. J Neurosci Methods 136:111-21
Ashjian, Peter; Elbarbary, Amir; Zuk, Patricia et al. (2004) Noninvasive in situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy. Tissue Eng 10:411-20
Jo, Javier A; Blasi, Anna; Valladares, Edwin et al. (2003) Model-based assessment of autonomic control in obstructive sleep apnea syndrome during sleep. Am J Respir Crit Care Med 167:128-36
Belozeroff, Vasily; Berry, Richard B; Khoo, Michael C K (2003) Model-based assessment of autonomic control in obstructive sleep apnea syndrome. Sleep 26:65-73
Bading, James R; Yoo, Paul B; Fissekis, John D et al. (2003) Kinetic modeling of 5-fluorouracil anabolism in colorectal adenocarcinoma: a positron emission tomography study in rats. Cancer Res 63:3667-74
Xu, Lu; Eiseman, Julie L; Egorin, Merrill J et al. (2003) Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite in tumor-bearing mice. J Pharmacokinet Pharmacodyn 30:185-219

Showing the most recent 10 out of 84 publications