WE HAVE CONCENTRATED CONSIDERABLE EFFORT ON THE SYNTHESIS OF 15N LABELLED BASES VIA THE NEW AND VERSATILE METHOD. WE HAVE COMPLETED THE SYNTHESIS OF [6,7,9 15N3]ADENINE. TREATMENT OF THE 4,6-DICHLOROPYRIMIDINE WITH 4 EQUIVALENTS OF AMMONIUM HYDROXIDE AFFORDS THE 4,6-DIAMINOPYRIMIDINE IN 90% YIELD. REACTION OF THE LABELED DIAZONIUM SALT, FOLLOWED BY HYDROGENATION OF THE AZO COMPOUND, AFFORDS THE TRIPLY LABELED MATERIAL. ANNULATION WITH FORMIC ACID GIVES THE ADENINE IN NEARLY QUANTITATIVE YIELD.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR002231-12S1
Application #
3723153
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Los Alamos National Lab
Department
Type
DUNS #
City
Los Alamos
State
NM
Country
United States
Zip Code
87545
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