This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NMR time is requested to investigate the structure of a lethal mutation within yeast U6 snRNA. We will compare the effects of the lethal point mutation to our previously solved structure, in order to better understand the structure and function of U6 snRNA in pre-messenger RNA splicing.
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