Abstract

High resolution imaging techniques using noninvasive modalities such as magnetic resonance imaging have been pursued as in vivo cancer screening techniques in an attempt to eliminate the invasive nature of surgical biopsy. The resolution and field of view attainable with magnetic resonance imaging has been limited in the past due to aliasing of the image. We present here a technique that uses this aliasing to produce high resolution images with larger matrix sizes than are currently available. It is performed in two dimensions, the frequency encoding and phase encoding direction, and the image is allowed to alias in both. The individual, aliased fields of view can be recovered by encoding the spatial information within the plane of the image using Hadamard methods. These images may then be tiled to obtain a composite image with high spatial resolution and a large field of view. This technique is demonstrated using two-dimensional and three-dimensional in vivo imagin g of the human brain and breast.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002305-18
Application #
6495459
Study Section
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
18
Fiscal Year
2001
Total Cost
$225,543
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Pang, Henry; Bow, Cora; Cheung, Jason Pui Yin et al. (2018) The UTE Disc Sign on MRI: A Novel Imaging Biomarker Associated With Degenerative Spine Changes, Low Back Pain, and Disability. Spine (Phila Pa 1976) 43:503-511
Ferraro, Pilar M; Jester, Charles; Olm, Christopher A et al. (2018) Perfusion alterations converge with patterns of pathological spread in transactive response DNA-binding protein 43 proteinopathies. Neurobiol Aging 68:85-92
Ercan, Altan; Kohrt, Wendy M; Cui, Jing et al. (2017) Estrogens regulate glycosylation of IgG in women and men. JCI Insight 2:e89703
Xie, Long; Dolui, Sudipto; Das, Sandhitsu R et al. (2016) A brain stress test: Cerebral perfusion during memory encoding in mild cognitive impairment. Neuroimage Clin 11:388-397
Yadav, Santosh K; Kathiresan, Nagarajan; Mohan, Suyash et al. (2016) Gender-based analysis of cortical thickness and structural connectivity in Parkinson's disease. J Neurol 263:2308-2318
Finkelstein, Joel S; Lee, Hang; Leder, Benjamin Z et al. (2016) Gonadal steroid-dependent effects on bone turnover and bone mineral density in men. J Clin Invest 126:1114-25
Rosenbaum, Michael; Leibel, Rudolph L (2016) Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring) 24:1620-9
Machida, Manabu; Panasyuk, George Y; Wang, Zheng-Min et al. (2016) Radiative transport and optical tomography with large datasets. J Opt Soc Am A Opt Image Sci Vis 33:551-8
Ban, H Y; Schweiger, M; Kavuri, V C et al. (2016) Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry. Med Phys 43:4383
Haris, Mohammad; Yadav, Santosh K; Rizwan, Arshi et al. (2015) T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease. Neuroimage Clin 7:598-604

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