This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to develop and validate a method for concurrent measurement of cerebral blood flow (CBF) and glucose metabolism using multimodal imaging with MRI and PET. Recently optimized arterial spin labeled (ASL) perfusion technique in subprojects 0008, 0053 and 0061 is used to evaluate the effects of HIV-associated neurocognitive impairment on caudate blood flow and volume. Decreasing trends in caudate blood flow and volume were associated with significantly increasing HIV-associated neurocognitive impairment (HNCI), with the greatest decreases observed for more severely impaired patients.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002305-22
Application #
7357851
Study Section
Special Emphasis Panel (ZRG1-SBIB-H (40))
Project Start
2006-06-01
Project End
2007-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
22
Fiscal Year
2006
Total Cost
$91,207
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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