This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project uses arterial spin labeled (ASL) perfusion functional MRI (fMRI) to monitor changes in resting CBF and regional brain activation during cocaine craving in patients with cocaine addiction. Recently optimized arterial spin labeled (ASL) perfusion technique in subprojects 0008, 0053 and 0061 is used to evaluate the effects of HIV-associated neurocognitive impairment on caudate blood flow and volume. Decreasing trends in caudate blood flow and volume were associated with significantly increasing HIV-associated neurocognitive impairment (HNCI), with the greatest decreases observed for more severely impaired patients.
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