This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Arterial spin labeling (ASL) perfusion MRI is an emerging technology to directly measure cerebral blood flow (CBF) by utilizing magnetically labeled arterial blood water as endogenous tracer. Continuous and pulsed ASL are two general strategies in carrying out spin labeling. In continuous ASL (CASL) , flow-driven adiabatic inversion is used to label arterial blood water flowing through the inversion plane during a time window of a few seconds. Pulsed ASL (PASL) uses nearly instantaneous inversion of spins in a slab proximal to the imaged tissue. The CASL technique was invented at the University of Pennsylvania in 1991, and has been applied on numerous subjects at 1.5T in our lab during these years. Recently, we have also implemented a robust version of PASL technique at both 1.5T and 4.0T.
The specific aims for this project are 1) to measure the accuracy and reproducibility of ASL perfusion MRI, 2) to apply the application of ASL in cerebrovascular disease and 3) to compare ASL perfusion MRI vs dynamic susceptibility contrast perfusion MRI.
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