This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Osteoarthritis(OA) is the most common form of arthritis, and it is highly prevalent in the elderly. T1rho-weighted MRI has shown promise as a diagnostic measure of early osteoarthritis (OA). The T1rho relaxation time during a spin-locking pulse has enhanced sensitivity to the interaction between bulk water molecules and extracellular matrix macromolecules such as the proteoglycans in the articular cartilage. In this study, we evaluated the efficacy of T1rho MRI in determining the OA changes in an animal model (Dunkin-Hartley guinea pig) of spontaneous OA. Guinea pigs of young and old age groups (2.5 month and 9 month-old accordingly) are imaged with a T1rho MRI pulse sequence, and their cartilage T1rho values were measured at the femoral-tibial joint.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002305-23
Application #
7600806
Study Section
Special Emphasis Panel (ZRG1-SBIB-H (40))
Project Start
2007-06-01
Project End
2008-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
23
Fiscal Year
2007
Total Cost
$22,015
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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