This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study, funded by K23HL092229, is to compare carotid MR plaque imaging at 7 Tesla (7T) with histological controls using carotid endarterectomy specimens. To date, most carotid plaque imaging has been conducted at lower magnetic field strengths (i.e. 1.5 or 3.0 Tesla) and little is known about the performance of carotid plaque imaging at 7T. Magnetic field strength is a primary determinant of image quality. However, magnetic field strength is also associated with specific changes to the technical aspects of the pulse sequences. For example, higher magnetic fields have a significant effect on T1 relaxation times of different tissues, resulting in significant differences in signal intensities. Therefore, we hypothesize that carotid plaque imaging at 7T will be associated with several technical improvements in the image quality: Hypothesis #1: In comparison to previously reported findings at 1.5 and 3.0T, carotid MRI at 7T will be associated with higher signal to noise ratios, improved spatial resolution, and reduced scan times. Hypothesis #2: In comparison to previously reported findings at 1.5 and 3.0T, carotid MRI at 7T will be associated with longer T1 times for carotid plaque components (i.e. hemorrhage, fibrous tissue, lipid-rich necrotic core). Hypothesis #3: In comparison to previously reported findings at 1.5 and 3.0T, carotid MRI at 7T will be associated with better agreement with histology as the gold standard using standard statistical techniques. Because these analyses will be performed on carotid endarterectomy specimens that have already been surgically removed (i.e. surgical waste), the present study exposes the patients to no risk. In contrast, because of the clinical importance of improved techniques for carotid plaque characterization, the present study has the potential to improve the ability to measure plaque characteristics non-invasively using MRI techniques. In the future, significant improvements in technique could translate into an overall benefit for patients, allowing for better patient selection to guide treatment strategies in patients with carotid artery disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002584-22
Application #
7956988
Study Section
Special Emphasis Panel (ZRG1-SBIB-Q (40))
Project Start
2009-09-01
Project End
2010-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
22
Fiscal Year
2009
Total Cost
$17,838
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Chiu, Tsuicheng D; Arai, Tatsuya J; Campbell Iii, James et al. (2018) MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors. PLoS One 13:e0198065
Mishkovsky, Mor; Anderson, Brian; Karlsson, Magnus et al. (2017) Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance. Sci Rep 7:11719
Moreno, Karlos X; Harrison, Crystal E; Merritt, Matthew E et al. (2017) Hyperpolarized ?-[1-13 C]gluconolactone as a probe of the pentose phosphate pathway. NMR Biomed 30:
Funk, Alexander M; Anderson, Brian L; Wen, Xiaodong et al. (2017) The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose. J Magn Reson 284:86-93
Walker, Christopher M; Merritt, Matthew; Wang, Jian-Xiong et al. (2016) Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents. J Vis Exp :e53607
Wu, Yunkou; Zhang, Shanrong; Soesbe, Todd C et al. (2016) pH imaging of mouse kidneys in vivo using a frequency-dependent paraCEST agent. Magn Reson Med 75:2432-41
Malloy, Craig R; Sherry, A Dean (2016) Biochemical Specificity in Human Cardiac Imaging by 13C Magnetic Resonance Imaging. Circ Res 119:1146-1148
Moss, Lacy R; Mulik, Rohit S; Van Treuren, Tim et al. (2016) Investigation into the distinct subcellular effects of docosahexaenoic acid loaded low-density lipoprotein nanoparticles in normal and malignant murine liver cells. Biochim Biophys Acta 1860:2363-2376
Bastiaansen, Jessica A M; Merritt, Matthew E; Comment, Arnaud (2016) Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate. Sci Rep 6:25573
Xing, Yixun; Jindal, Ashish K; Regueiro-Figueroa, Martín et al. (2016) The Relationship between NMR Chemical Shifts of Thermally Polarized and Hyperpolarized 89 Y Complexes and Their Solution Structures. Chemistry 22:16657-16667

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