This is a proposal to the National Institute of Health for continued support of the MIT Laser Biomedical Research Center (LBRC), a research resource center in laser biomedicine established in October, 1985 through the NIH Biomedical Research Technology Program. New and continuing activities are proposed in five categories: [1] core research and development will occur in (a) optical histochemistry, techniques and instrumentation; such studies include laser induced fluorescence and vibrational spectroscopy of tissue for new diagnostic methods of disease without biopsy; (b) molecular mechanisms of tissue alteration, techniques and instrumentation; this area includes development of new laser systems for use with optical fibers for microsurgery and for a basic understanding of ablation processes. and (c) biophysics of polymer conformations and dynamics; work includes Raman and vibrational spectroscopy of new phases in gels, picosecond and femtosecond dynamics optico-ultrasonic tomography and other areas. [2] collaborative research will occur in all of the above areas; [3] projects of outside researchers will continue to be supported using existing and new facilities and staff; [4] training and education will continue to be provided through hands-on laboratory experience, seminars and intensive one-day workshop-minicourse programs; [5] dissemination of information will continue through our publication, """"""""The Spectrograph"""""""", and other reports. Several laboratories for medical research will be substantially expanded. These new facilities, together with the existing LBRC resources, will be available to collaborative and outside researchers.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002594-10
Application #
2281670
Study Section
Special Emphasis Panel (ZRG7-SSS-1 (02))
Project Start
1985-09-30
Project End
1996-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Shih, Wei-Chuan; Bechtel, Kate L; Rebec, Mihailo V (2015) Noninvasive glucose sensing by transcutaneous Raman spectroscopy. J Biomed Opt 20:051036
Dudzik, Jonathan; Chang, Wen-Chi; Kannan, A M et al. (2013) Cross-linked glucose oxidase clusters for biofuel cell anode catalysts. Biofabrication 5:035009
Sathyavathi, R; Dingari, Narahara Chari; Barman, Ishan et al. (2013) Raman spectroscopy provides a powerful, rapid diagnostic tool for the detection of tuberculous meningitis in ex vivo cerebrospinal fluid samples. J Biophotonics 6:567-72
Dingari, Narahara Chari; Barman, Ishan; Saha, Anushree et al. (2013) Development and comparative assessment of Raman spectroscopic classification algorithms for lesion discrimination in stereotactic breast biopsies with microcalcifications. J Biophotonics 6:371-81
Cooper, Kimberly L; Oh, Seungeun; Sung, Yongjin et al. (2013) Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature 495:375-8
Sung, Yongjin; Tzur, Amit; Oh, Seungeun et al. (2013) Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A 110:16687-92
Lau, Condon; Mirkovic, Jelena; Yu, Chung-Chieh et al. (2013) Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging. J Biomed Opt 18:76013
Soares, Jaqueline S; Barman, Ishan; Dingari, Narahara Chari et al. (2013) Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications. Proc Natl Acad Sci U S A 110:471-6
Byun, HeeSu; Hillman, Timothy R; Higgins, John M et al. (2012) Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient. Acta Biomater 8:4130-8
Dingari, Narahara Chari; Barman, Ishan; Myakalwar, Ashwin Kumar et al. (2012) Incorporation of support vector machines in the LIBS toolbox for sensitive and robust classification amidst unexpected sample and system variability. Anal Chem 84:2686-94

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