When analyte concentrations are predicted from spectral data, the mean prediction error decreases as the signal-to-noise of the spectrum increases. However, medical situations often place an upper limit on the amount of time that a clinical measurement can take. The time constraint, in turn, limits the signal-to-noise ratio that can be achieved. Therefore, when we design calibrations for analyte prediction, it is important to study how the prediction accuracy changes as a function of collection time. Our preliminary investigations, using our data on blood serum, have indicated that we can decrease the measurement time for unknown samples to as little as 30 or 60 seconds while preserving a clinical level of prediction accuracy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002594-14
Application #
6121236
Study Section
Project Start
1999-06-01
Project End
2000-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
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Cooper, Kimberly L; Oh, Seungeun; Sung, Yongjin et al. (2013) Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature 495:375-8
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Dingari, Narahara Chari; Barman, Ishan; Myakalwar, Ashwin Kumar et al. (2012) Incorporation of support vector machines in the LIBS toolbox for sensitive and robust classification amidst unexpected sample and system variability. Anal Chem 84:2686-94

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