Abstract

Actinic prurigo is an idiopathic photodermatosis seen in American Indians; the face and other sun-exposed areas are usually involved, the patients being sensitive to ultraviolet A light. A modified dominant form of inheritance has been proposed for the disease, but formal segregation analysis has never been performed. Large pedigrees of Cree Indians and M?tis (mixed American Indian and white) of Cree ancestry have been ascertained in which the disease appears to be segregating and detailed data on relationships and age of onset are being collected. Data collection is now complete and segregation analysis is being performed to confirm or refute a single gene mode of inheritance.?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR003655-15
Application #
6348130
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
2000
Total Cost
$7,508
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Elston, Robert C; Satagopan, Jaya; Sun, Shuying (2017) Statistical Genetic Terminology. Methods Mol Biol 1666:1-9
Thota, Prashanthi N; Zackria, Shamiq; Sanaka, Madhusudhan R et al. (2017) Racial Disparity in the Sex Distribution, the Prevalence, and the Incidence of Dysplasia in Barrett's Esophagus. J Clin Gastroenterol 51:402-406
Liang, Jingjing; Cade, Brian E; Wang, Heming et al. (2016) Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses. Genet Epidemiol 40:222-32
Wang, Chuchu; Wu, Manman; Qian, Jin et al. (2016) Identification of rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population. Mol Genet Genomics 291:79-92
Lemas, Dominick J; Klimentidis, Yann C; Aslibekyan, Stella et al. (2016) Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Mol Nutr Food Res 60:2642-2653
Day, Kenneth; Waite, Lindsay L; Alonso, Arnald et al. (2016) Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects. PLoS One 11:e0165488
Justice, Cristina M; Bishop, Kevin; Carrington, Blake et al. (2016) Evaluation of IRX Genes and Conserved Noncoding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis. G3 (Bethesda) 6:1707-12
Petrovic, Dusan; Pivin, Edward; Ponte, Belen et al. (2016) Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study. Psychoneuroendocrinology 67:76-85
Greer, Katarina B; Falk, Gary W; Bednarchik, Beth et al. (2015) Associations of Serum Adiponectin and Leptin With Barrett's Esophagus. Clin Gastroenterol Hepatol 13:2265-72
Alwan, Heba; Ehret, Georg; Ponte, Belen et al. (2015) Heritability of ambulatory and office blood pressure in the Swiss population. J Hypertens 33:2061-7

Showing the most recent 10 out of 922 publications