This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to investigate the role(s) of intermediate filaments in reaction of astrocytes to CNS injury using astrocyte dye-filling/imaging protocols developed at NCMIR. The project's specific aims are to: 1) Visualize the morphology of reactive and non-reactive wild type astrocytes and astrocytes devoid of intermediate filaments (GFAP & Vimentin). 2) Qualititatively confirm the decrease in process length in GFAP-/-vimentin-/- reactive astrocytes (previously characterized using glutamine synthase immunohistochemistry).
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