This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Cartilage matrix components have been shown to vary in content and organization with age and vertical depth from the articular surface. This structural variation has been correlated to the anisotropic mechanical properties of cartilage. However, most of the structural studies of collagen have been performed on unstressed cartilage, and any changes that occur in the collagen structure during load have not been well-characterized. Determining the effect of tension on collagen fibril structure would help elucidate how cartilage tissue structure relates to its biomechanical function. The objective of this study is to elucidate changes in collagen structure in tension with varying depths and ages of bovine knee cartilage.
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