The Complex Carbohydrate Research Center (CCRC) of the University of Georgia proposes the establishment of a Resource Center for Biomedical Complex Carbohydrates. The Resource Center would be organized around the following four core research areas: Structural Analysis of Complex Carbohydrates of Animal Origin, Conformational Analysis of Complex Carbohydrates of Animal Origin, Enzymes Involved in the Synthesis and Depolymerization of Complex Carbohydrates of Animal Origin, and Separation Technology of Animal-Cell-Derived Oligosaccharides. Each Core Research Area includes Core and Collaborative Research Projects. Typical Core Research Projects are the development of an improved method for determining the glycosyl-residue composition of complex carbohydrates, the development of a sensitive fingerprinting technique for complex carbohydrates, the development of a computer-assisted method for identifying carbohydrates from their NMR and mass spectra, the development if methods for determining the conformation of the carbohydrate chains of intact glycoproteins and large glycopeptides, the development of improved methods for assaying glycosyl transferases and glycosidases, and the development of improved methods of affinity chromatography for separating complex carbohydrates. The Center also proposes to establish a Carbohydrate Information Facility that includes development of a laboratory information system for carbohydrate sciences. The information facility would make available to the scientific community carbohydrate science databases including three-dimensional structures of carbohydrates, NMR and mass spectra of carbohydrates, and bibliographic information on carbohydrates. The Resource Center will offer a variety of analytical services and short courses for scientists of other institutions, and will form an Advisory Committee to set priorities and resolve technical problems.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
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Hannides, Angelos K; Aller, Robert C (2016) Priming effect of benthic gastropod mucus on sedimentary organic matter remineralization. Limnol Oceanogr 61:1640-1650
Revoredo, Leslie; Wang, Shengjun; Bennett, Eric Paul et al. (2016) Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family. Glycobiology 26:360-76
Zhao, Wujun; Zhu, Taotao; Cheng, Rui et al. (2016) Label-Free and Continuous-Flow Ferrohydrodynamic Separation of HeLa Cells and Blood Cells in Biocompatible Ferrofluids. Adv Funct Mater 26:3990-3998
Wu, Liang; Viola, Cristina M; Brzozowski, Andrzej M et al. (2015) Structural characterization of human heparanase reveals insights into substrate recognition. Nat Struct Mol Biol 22:1016-22
Qiu, Hong; Xiao, Wenyuan; Yue, Jingwen et al. (2015) Heparan sulfate modulates Slit3-induced endothelial cell migration. Methods Mol Biol 1229:549-55
Li, Zixuan; Moniz, Heather; Wang, Shuo et al. (2015) High structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin binding interface. J Biol Chem 290:10729-40
Czuchry, Diana; Desormeaux, Paul; Stuart, Melissa et al. (2015) Identification and Biochemical Characterization of the Novel ?2,3-Sialyltransferase WbwA from Pathogenic Escherichia coli Serotype O104. J Bacteriol 197:3760-8
Liu, Lin; Zha, Jingying; DiGiandomenico, Antonio et al. (2015) Synthetic Enterobacterial Common Antigen (ECA) for the Development of a Universal Immunotherapy for Drug-Resistant Enterobacteriaceae. Angew Chem Int Ed Engl 54:10953-7
Zhang, Fuming; Moniz, Heather A; Walcott, Benjamin et al. (2014) Probing the impact of GFP tagging on Robo1-heparin interaction. Glycoconj J 31:299-307
Zarnowski, Robert; Westler, William M; Lacmbouh, Ghislain Ade et al. (2014) Novel entries in a fungal biofilm matrix encyclopedia. MBio 5:e01333-14

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