Fiber orientation mapping has been performed with anisotropic diffusion measurements using conventional spin echo techniques. However, the multiple diffusion measurements required by the method can be time consuming. Fast spin echo (FSE) techniques has potential for improving the time efficiency of the data acquisition, albeit it has not been shown experimentally. Fiber orientation will be performed on a phantom (cotton/silk threads in water) to (a) compare the accuracy and efficiency of fiber orientation mapping using conventional spin echo and FSE based techniques, and (b) investigate the advantages of using bipolar diffusion-weighting gradients in place of conventional Stejskal-Tanner pulsed gradients. The latter includes theoretical treatment of the effects of gradient cross-terms and imperfect refocussing pulses in FSE.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR005959-11
Application #
6348147
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
11
Fiscal Year
2000
Total Cost
$30,035
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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