Morphologic images of the lung have been obtained in excellent quality in small animals and humans in vivo using hyperpolarized (HP) noble gas MRI. Whereas 3He seems to be superior regarding imaging of the lung gas spaces, 129Xe has some unique properties which makes it a potential probe for pulmonary perfusion: (a) xenon has a decent solubility in blood and tissues, (b) the large range of 129Xe chemical shifts in vivo (approx. 200 ppm between gas and tissue phases) can be used for the selective investigation of xenon in different environments, such as alveolar gas space, pulmonary blood and parenchyma. While the frequency separation between xenon in parenchymal tissue and pulmonary blood is small, the differences in the motional behavior of both compartments can be used for the exclusive selection of the blood pool: rapid application of large flip angles leads to a saturation of the parenchyma signal whereas uptake of HP 129Xe by the blood is repeated with each cardiac cycle. Purpose of the project is therefore the selective imaging of HP 129Xe dissolved in the pulmonary blood as a measure of local pulmonary perfusion. Initial spectroscopy studies will be used to develop projection-encoding strategies for non-slice-selective 2D imaging with chemical-shift-selective excitation and detection.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR005959-11
Application #
6348173
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
11
Fiscal Year
2000
Total Cost
$3,756
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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