This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this proposal is to detect iron-oxide labeled, transplanted cells in spinal cord and kidney specimen. The applicant has been doing similar work at Robarts at 1.5T using a 3DFIESTA imaging sequence. We would like to ask the simple question of whether there are advantages to using high field for imaging iron labeled cells. All of the investigator's previous studies in cellular imaging have been conducted at 1.5T with SSFP and high powered custom-built gradient coil inserts. High field may introduce new difficulties in the form of off-resonance artifacts. But cell detection improves with increasing SNR (to a certain degree) and with decreasing voxel volume. We are currently limited to 100 microns isotropic spatial resolution at 1.5T. Results from work done at 1.5T at Robarts will be compared with 9.4T data from the Duke Center for In Vivo Microscopy.
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