This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this work are to establish a correspondence between skull-based landmarks used traditionally to define a stereotaxic coordinate system and internal brain landmarks that could be used instead. The transformation between the two coordinates systems will be deduced within the limits of normal biological variability. We will start with the rat, where we have more signal and move to the mouse as we are able to refine the scanning method. Advantages of using both rat and mouse is to be able to look for similarities/differences in the anatomy. We will look for the barrel field in a high-resolution T1 scan of a fixed, stained brain and try to observe the columnar organization of the cortex.
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