This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of these pilot studies are to establish the feasibility of MR imaging to track a unique population of adipose-derived stem (ADS) cells harvested from adult adipose tissue. Previous work from our laboratory and others has established the potential of ASCs to differentiate in vitro into cells with neuronal and glial properties, as well as these cells to survive, migrate, and differentiate in vivo after transplantation into the rodent brain. In these proposed pilot studies, we will examine the feasibility of using MR microimaging to track these cells in a rodent model of stroke. These studies should complement our long-term characterization of ADS cells as an alternative tissue source for neuronal cellular therapies as well as to establish the role for MR imaging of adipose-derived stem cells in various animal models. These pilot studies are intended to examine the feasibility of these techniques as well as to gather preliminary data to be included with a new R21 NIH grant application in response to a Program Announcement (PA-04-130, Collaborative Research in Stem Cell Biology). We plan to submit this proposal for a Feb. 1, 2005 deadline.
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