This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Investigators from around the world see images produced at the Center and gain insight into our work through our web site, publications, and presentations at technical meetings. We share data from the Center to support their research. Examples are listed below: To Stana Mihajlovic, Business Development Manager, Resonance Research, Inc., Billerica, MA to use in a presentation at upcoming annual ISMRM conference; Libby Bucholz, graduate student who develops 4D cardiac imaging for the mouse, shared Quicktime movies and static images from the 3D radial sequence that acquired the 4th dimension (~ 10 ms intervals through the cardiac cycle). To: Craig Hernandez (Duke Biomedical Engineering), Cristian Badea shared two cardiac micro-CT datasets.APRIL 26: Jeff Brandenburg shared 4D digital mouse phantom software as viewed in Paul Segar's paper---GET NAME OF PERSONTo: Dr. Susumu Mori, Johns Hopkins, shared dataset of an example of one of CIVM's 40-micron T2-weighted mouse brain images, and in addition shared figures from manuscript: M Cyr, MG Caron, GA Johnson, A Laakso, Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mousemodel of dopaminergic hyperfunction, NeuroImage 26(1): 83-90, 2005.To aid Sommer Amundsen, student in summer research program, Milwaukee School of Engineering project o use rapid prototyping technology to create a mechanical model of the middle ear which would show the vibration mechanics of the ear as accurately as possible, sent information concerning scanning of cochleas in collaboration with Miriam and Bill Henson at UNC-Chapel Hill.For: Raul Braumer, President/CEO, Bio-Tree, Framingham, MA; Cristian Badea shared micro-CT datasets of a mouse and a rat, using a blood pool contrast agent, Fenestra VC, for the purpose of an exploratory experiment to validate the Center's in-vivo imaging capabilities as a precursor for possible collaboration.For Colin Kazina MD, 4th year Neurosurgery resident and Biosystems Engineering student at University of Manitoba, studying the biomechanical properties of the brain. Inquired of Laurence Hedlund suggestions for the best suited pressure-controlled animal ventilator available. LW Hedlund answered some questions, and forwarded reprints of LW Hedlund, GA Johnson, Mechanical ventilation for imaging the small animal. ILAR J 43(3): 159-174, 2002 and LW Hedlund, et al., MR-compatible ventilator for small animals: computer-controlled ventilator for proton and noble gas imaging, Magn Reson Imag 18: 753-759, 2000.For: Martin Styner, PhD. Eng. ETH, Research Assistant Professor, Neurodevelopmental Disorders Research Center, Computer Science and Psychiatry, UNC-Chapel Hill; preliminary existing Reeler brain data shared for 'Advanced image analysis of the rodent brain,' to apply UNC segmentation tools on CIVM high resolution, actively stained data, to judge effectiveness on this new type of input. If the warping step produces meaningful output, the UNC segmentation algorithm be applied.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
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Duke University
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Tang, Xinyan; Jing, Liufang; Richardson, William J et al. (2016) Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. J Orthop Res 34:1316-26
Hodgkinson, Conrad P; Bareja, Akshay; Gomez, José A et al. (2016) Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Circ Res 118:95-107
Schmeckpeper, Jeffrey; Verma, Amanda; Yin, Lucy et al. (2015) Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. J Mol Cell Cardiol 85:215-25
Roos, Justus E; McAdams, Holman P; Kaushik, S Sivaram et al. (2015) Hyperpolarized Gas MR Imaging: Technique and Applications. Magn Reson Imaging Clin N Am 23:217-29
He, Mu; Robertson, Scott H; Kaushik, S Sivaram et al. (2015) Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging 33:877-85
Huang, Lingling; Walter, Vonn; Hayes, D Neil et al. (2014) Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. Clin Cancer Res 20:1566-75
Huang, Jing; Guo, Jian; Beigi, Farideh et al. (2014) HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. J Mol Cell Cardiol 66:157-64
Yuan, Ying; Gilmore, John H; Geng, Xiujuan et al. (2014) FMEM: functional mixed effects modeling for the analysis of longitudinal white matter Tract data. Neuroimage 84:753-64
He, Mu; Kaushik, S Sivaram; Robertson, Scott H et al. (2014) Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. Acad Radiol 21:1530-41
van Rhoon, Gerard C; Samaras, Theodoros; Yarmolenko, Pavel S et al. (2013) CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? Eur Radiol 23:2215-27

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