This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The NC mice have be bidirectionally selected over 45 generations for aggressive behaviors. The NC100 mice are affiliative, while the NC900 mice are highly aggressive. In conducting neurochemical studies in these mice, we have found that the levels of serotonin in brain are reduced in the aggressive mice. In dissecting the brain and examining nissel stained section, we find that the brain structure appear to be somewhat altered -- especially in amygdala and in pons/midbrain (where serotonergic neurons reside). I would like to examine one brain each of NC100 and NC900 mice to determine whether differences can be detected by MRI using the new procedure outlined in Neuroimage 27:425-435 (2005). If we get some mouse line differences, this information could serve as preliminary data for a grant.
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