NMR microscopy has been developed for in vitro and in vivo applications at cellular resolution. Various radio frequency and gradient coil geometries have been developed to maximize signal-to-noise ratio and spatial resolution depending on sample size and region of interest. Theoretical and experimental performance of these coils are in good agreement. Experimental confirmation of the predicted restricted diffusion effects is underway using gas and liquid phase samples. Efficient data sampling methods and image processing techniques are being developed to reduce the data acquisition time. New methods of NMR microscopy are being developed using diffusion to simultaneously increase sensitivity and resolution. Methods have been developed and theoretical results obtained that provide a more complete basis for interpreting microscopic NMR images in the presence and absence of restricted diffusion and of magnetic molecules and particles that alter relaxation times or local magnetic fields. The theory of diffusion-enhanced microscopy has been developed for one-, two-, and three-dimensional systems.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois at Chicago
United States
Zip Code
Li, Li; Palencia, Andrés; Lukk, Tiit et al. (2013) Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens. Proc Natl Acad Sci U S A 110:3817-22
Li, Li; Boniecki, Michal T; Jaffe, Jacob D et al. (2011) Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites. Proc Natl Acad Sci U S A 108:9378-83
Sallam, Khalid Ibrahim (2007) Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control 18:566-575
Sallam, Khalid Ibrahim (2007) Chemical, sensory and shelf life evaluation of sliced salmon treated with salts of organic acids. Food Chem 101:592-600
Sallam, Kh I; Samejima, K (2004) Microbiological and chemical quality of ground beef treated with sodium lactate and sodium chloride during refrigerated storage. Lebenson Wiss Technol 37:865-871
Moser, Kevin W; Georgiadis, John G (2004) Extraction and validation of correlation lengths from interstitial velocity fields using diffusion-weighted MRI. Magn Reson Imaging 22:257-68
Sallam, Kh I; Ishioroshi, M; Samejima, K (2004) Antioxidant and antimicrobial effects of garlic in chicken sausage. Lebenson Wiss Technol 37:849-855
Sallam, Khalid Ibrahim; Samejima, Kunihiko (2004) Effects of Trisodium Phosphate and Sodium Chloride Dipping on the Microbial Quality and Shelf Life of Refrigerated Tray-packaged Chicken Breasts. Food Sci Biotechnol 13:425-429
Tsao, Jeffrey (2003) Interpolation artifacts in multimodality image registration based on maximization of mutual information. IEEE Trans Med Imaging 22:854-64
Damon, Bruce M; Hsu, Alex C; Stark, Heather J et al. (2003) The carnosine C-2 proton's chemical shift reports intracellular pH in oxidative and glycolytic muscle fibers. Magn Reson Med 49:233-40

Showing the most recent 10 out of 55 publications