This study focuses on the structures and dynamics of nucleic acids and their complexes with anticancer drugs. The objective is the understanding of the conformational diversity of nucleic acids and the molecular interactions between antitumor drugs and DNA/RNA molecules using high resolution nuclear magnetic resonance spectroscopy. Several anthracycline drugs including daunorubicin, nogalamycin, and aclacinomycin A are being investigated. The study coordinates closely with the related nucleic acid systems that are being studied by the single crystal x-ray diffraction methods currently in use. Several molecular systems containing carefully selected DNA and RNA oligonucleotide sequences associated with important biological implications have been synthesized in sufficient quantities.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR005964-08
Application #
6282392
Study Section
Project Start
1998-01-15
Project End
1999-01-14
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Type
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Li, Li; Palencia, Andrés; Lukk, Tiit et al. (2013) Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens. Proc Natl Acad Sci U S A 110:3817-22
Li, Li; Boniecki, Michal T; Jaffe, Jacob D et al. (2011) Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites. Proc Natl Acad Sci U S A 108:9378-83
Sallam, Khalid Ibrahim (2007) Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control 18:566-575
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Sallam, Kh I; Samejima, K (2004) Microbiological and chemical quality of ground beef treated with sodium lactate and sodium chloride during refrigerated storage. Lebenson Wiss Technol 37:865-871
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Sallam, Kh I; Ishioroshi, M; Samejima, K (2004) Antioxidant and antimicrobial effects of garlic in chicken sausage. Lebenson Wiss Technol 37:849-855
Sallam, Khalid Ibrahim; Samejima, Kunihiko (2004) Effects of Trisodium Phosphate and Sodium Chloride Dipping on the Microbial Quality and Shelf Life of Refrigerated Tray-packaged Chicken Breasts. Food Sci Biotechnol 13:425-429
Tsao, Jeffrey (2003) Interpolation artifacts in multimodality image registration based on maximization of mutual information. IEEE Trans Med Imaging 22:854-64
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