Vascular bypass grafts have become important in the treatment of arterial obstructions, particularly for vessels in the heart and legs. If is well documented that hemodynamic factors influence the growth and adaptation of the arterial wall. In particular, these factors can accelerate or inhibit the excessive growth of vascular will (intimal thickening) and which can result in occlusive failure of the graft. Wall shear stress has long been considered an important variable in intimal thickening, but is only on of numerous contributing factors. The adhesion of platelets to the vessel wall and subsequent release of platelet-derived growth factor is also a necessary step for thrombosis, which can cause the final rapid occlusion of the graft opening. The path history of a platelet is important since these final rapid occlusion of the graft opening. The path history of a platelet is important since these cells can become activated by hemodynamic forces in one location and adhere in a different location. The proposed research will use numerical flow computations and particle tracing methods to determine the wall shear stress and the particle trajectories of platelets within an end-to-side anastomotic bypass graft. The results will be used to predict the growth of the vessel according to theoretical models derived from existing literature. To take this process to the point where the vessel occludes, the model must be altered and the flow field must be re-calculated for the altered geometry. This will demonstrate the feasibility of a much larger project in which models of the adaptive process are used to predict the evolution of the vessel wall over time. Once developed, it will be possible to use the technique to test specific biological models and to design appropriate graft geometries for patients with occlusive disease.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Simakov, Nikolay A; Kurnikova, Maria G (2018) Membrane Position Dependency of the pKa and Conductivity of the Protein Ion Channel. J Membr Biol 251:393-404
Yonkunas, Michael; Buddhadev, Maiti; Flores Canales, Jose C et al. (2017) Configurational Preference of the Glutamate Receptor Ligand Binding Domain Dimers. Biophys J 112:2291-2300
Hwang, Wonmuk; Lang, Matthew J; Karplus, Martin (2017) Kinesin motility is driven by subdomain dynamics. Elife 6:
Earley, Lauriel F; Powers, John M; Adachi, Kei et al. (2017) Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11. J Virol 91:
Murty, Vishnu P; Calabro, Finnegan; Luna, Beatriz (2016) The role of experience in adolescent cognitive development: Integration of executive, memory, and mesolimbic systems. Neurosci Biobehav Rev 70:46-58
Subramanian, Sandeep; Chaparala, Srilakshmi; Avali, Viji et al. (2016) A pilot study on the prevalence of DNA palindromes in breast cancer genomes. BMC Med Genomics 9:73
Ramakrishnan, N; Tourdot, Richard W; Radhakrishnan, Ravi (2016) Thermodynamic free energy methods to investigate shape transitions in bilayer membranes. Int J Adv Eng Sci Appl Math 8:88-100
Zhang, Yimeng; Li, Xiong; Samonds, Jason M et al. (2016) Relating functional connectivity in V1 neural circuits and 3D natural scenes using Boltzmann machines. Vision Res 120:121-31
Lee, Wei-Chung Allen; Bonin, Vincent; Reed, Michael et al. (2016) Anatomy and function of an excitatory network in the visual cortex. Nature 532:370-4
Jurkowitz, Marianne S; Patel, Aalapi; Wu, Lai-Chu et al. (2015) The YhhN protein of Legionella pneumophila is a Lysoplasmalogenase. Biochim Biophys Acta 1848:742-51

Showing the most recent 10 out of 292 publications