The focus of our research is on the regulation and function of rat lipopolysaccharide binding protein (LBP). LBP is a serum protein produced by the liver which forms a high affinity bond to bacterial lipopolysaccharides (LPS) and together this complex significantly upregulates the production of cytokines such as TNF by macrophages. LBP is felt to play significant role in the pathogenesis of septic shock. Our lab has recently cloned and sequenced a full length cDNA for rat LBP. We plan to proceed further and clone the rat promoter for LBP.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR006009-09S2
Application #
6122526
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Mellon Pitts Corporation (Mpc Corp)
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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