This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract: Molecular studies have recently implicated the P2Y2 receptor in the Raf, Mek, Erk1/2 MAPK pathway (Patel V. et.al. Biochem. J.320, 221-226(1996), Soltoff S. et.al. JBC 273(5), 2652-2660(1998). Acute inflammatory responses potentiated primarily by TNF-a and IL-1b released from mononuclear phagocytes have been correlated to P2X7 receptor function through an LPS-dependent process (Ferrari D. et.al. J. Exp. Med. 185)3), 579-582(1997), Bertics P. et.al. in press). Primary sequence analysis of various P2 nucleotide receptors reveals a variety of conserved ligands shown to associate with certain conserved modular domains within soluble factors. Hypothetical modeling studies will be a valuable tool in elucidating domains within P2 nucleotide receptors, the interface of which can provide new models and understanding of the roles of these receptors in various mammalian cell types.
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