This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: hemodynamics, biofluid mechanics, computational fluid dynamics Abstract:
The specific aims for this project are as follows: Evaluate the types and magnitutes of in-vivo physiologic flow forces applied to the EVG attachment/sealing system that would tend to dislodge the EVG and predict the mechanical forces induced by the interaction of EVG attachment/sealing mechanisims with the surrounding vascular wall. Computational and experimental models of deployed EVGs will be devloped to simulate pulsatile blood flow for average resting hemodynamic conditions, providing a time-dependent distribution of drag forces exerted on the graft. Design and develop a composite biomaterial that will interface with existing EVG passive and active attachment and sealing systems to promote tissue ingrowth for secure anchorage of the EVG to the inside of the AAA. Rigorous in-vitro testing of the tissue-engineered material will be comprised of both native and synthetic polymers, combining the two to result in a scaffold that will adhere to the graft as well as enhance remodeling of the vascular tissue.
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