This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.PSC and the Duke Center for In Vivo Microscopy are collaboratingto apply PSC's volumetric anatomy visualization and analysis toolsto micro-MRI mouse data sets. Micro-MRI data will be captured usingthe MRI scanners at Duke to capture full mouse volumes at ~30micronresolution over a series of mouse speciments at a series of developmentstages and with various gene knockouts. Data will be reassembledinto 4D datasets to be used with PSC's Volume Browser/Volume Serverfor registration, segmention and anatomical comparisons. This workis in the proof of principle stage for proposal preparation.High performance computing resources are needed for data storage, visualization and segmentation processing. Each volumetric time pointis 1Gbyte of data and we anticipate 8 to 16 time points per specimen.Initially we will be working with one specimen but if the projectis funded this will eventually expand to several hundred.
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