This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The tri-modal spectroscopy (TMS) project of the Laser Biomedical Research Center (an NIH P41 Research Resource) employs the combination of light scattering, diffuse reflectance and intrinsic fluorescence spectroscopy to detect pre-cancer (epithelial dysplasia). Studies are being conducted on human subjects in vivo and on ex vivo tissue specimens. There is a pressing need to develop Monte Carlo simulations based on radiative transport to model the spectral signals. The results will provide information to improve TMS analysis and provide insight as to the way the morphological and biochemical tissue components manifest themselves in the optical signals. We have developed a Monte Carlo code and are using it in preliminary studies. However, because the numerical simulations are time consuming, a large parallel processing computer is required.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR006009-18
Application #
7723212
Study Section
Special Emphasis Panel (ZRG1-BCMB-Q (40))
Project Start
2008-08-01
Project End
2009-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
18
Fiscal Year
2008
Total Cost
$473
Indirect Cost
Name
Carnegie-Mellon University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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