Funds are requested to establish a BIOMEDICAL RESEARCH TECHNOLOGY REGIONAL RESOURCE to conduct magnetic resonance imaging and spectroscopy research at 4 Tesla magnetic fields. Until recently, human applications of magnetic resonance imaging (MRI), which has evolved to become an indispensable tool in clinical medicine, has been conducted at 2 Tesla or lower fields. Although, spectroscopy studies with animal models are most successfully conducted at higher fields, such as 4.7 Tesla and 7 Tesla, human applications have also been restricted to 2 Tesla or less, and has achieved only limited success. The University of Minnesota, Center for Magnetic Resonance, has recently installed a 4 Tesla/125 Bore whole body MR imaging/spectroscopy system. This is one of three 4 Tesla systems in the world located in non-industrial research laboratories. The availability of such systems provide for the first time the opportunity to a) develop unique spectroscopy and imaging applications that are either difficult or impossible to perform at lower magnetic fields, b) bring human MR spectroscopy into the SNR domain where it can have a significant impact on biomedical research and clinical medicine, as demonstrated with successful animal experiments at similarly high magnetic field strengths and c) examine the advantages and disadvantages of higher magnetic fields for imaging and spectroscopy with humans. A central aim of the Core and Collaborative projects, is to obtain simultaneous information on aspects of organ function, perfusion, oxygen extraction, metabolism, and anatomy in humans, non-invasively, and using the same modality. Four Tesla studies with such multifaceted information will be used to i) examine the validity of conclusions reached from animal model studies and ii) investigate biomedical problems in humans for which no animal models exist.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Special Emphasis Panel (SSS (41))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Schools of Medicine
United States
Zip Code
Herzberg, Max P; Hodel, Amanda S; Cowell, Raquel A et al. (2018) Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia 119:262-270
U?urbil, Kamil (2018) Imaging at ultrahigh magnetic fields: History, challenges, and solutions. Neuroimage 168:7-32
Foell, Jens; Palumbo, Isabella M; Yancey, James R et al. (2018) Biobehavioral threat sensitivity and amygdala volume: A twin neuroimaging study. Neuroimage 186:14-21
Magnitsky, Sergey; Pickup, Stephan; Garwood, Michael et al. (2018) Imaging of a high concentration of iron labeled cells with positive contrast in a rat knee. Magn Reson Med :
Lee, Byeong-Yeul; Zhu, Xiao-Hong; Woo, Myung Kyun et al. (2018) Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter-receiver and dynamic B0 shimming. NMR Biomed 31:
Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2018) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med 48:1673-1684
Bolan, Patrick J; Kim, Eunhee; Herman, Benjamin A et al. (2017) MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial. J Magn Reson Imaging 46:290-302
Nelson, Brent G; Bassett, Danielle S; Camchong, Jazmin et al. (2017) Comparison of large-scale human brain functional and anatomical networks in schizophrenia. Neuroimage Clin 15:439-448
Tremblay, Sara; Lafleur, Louis-Philippe; Proulx, S├ębastien et al. (2016) The effects of bi-hemispheric M1-M1 transcranial direct current stimulation on primary motor cortex neurophysiology and metabolite concentration. Restor Neurol Neurosci 34:587-602
Kennedy, James T; Collins, Paul F; Luciana, Monica (2016) Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes and Lower Levels of Positive Emotionality. Front Neurosci 10:413

Showing the most recent 10 out of 493 publications