Abstract

This collaborative effort is supported by an NIH grant for human fMRI studies (R01 NS 32919, 7/15/94- 4/30/97). The overall goal of this project is to determine the spatio-temporal patterns of functional activation of cortical areas during performance of specific perceptual-motor cognitive tasks, as revealed by high field functional magnetic resonance imaging in human brain.
SPECIFIC AIMS are: 1. To determine the spatio-temporal patterns of functional activation of cortical areas during visual and motor mental rotation in the human brain using fMRI and correlate activation in these areas with behavioral data obtained simultaneously with the MR images. Specifically, this project is aimed (a) to identify the areas involved during mental rotation of visual images and during generation of movements at an angle from a stimulus direction, and (b) to test the hypotheses that these cognitive processes (i) involve the sequential activation of specific cortical areas, and (ii) rely on the activation of certain common cortical areas. 2. To determine the spatio-temporal patterns of functional activation of cortical areas during visual and motor memory scanning. This project is aimed (a) to identify the areas involved during memory scanning of visual images and during generation of movements based on memory scanning of a previous sequence, and (b) to test the hypotheses that these cognitive processes (i) involve the sequential activation of specific cortical areas, and (ii) rely on the activation of common cortical areas. 3. To compare the spatio-temporal patterns of functional activation of cortical areas obtained during mental rotation and memory scanning. This comparison will serve to differentiate the cortical substrates involved in these two different kinds of cognitive processes . In the last year, significant progress has been made towards aims 1 and 2 and partially into specific aim 3. Currently data are being collected on specific aim 3. Two papers are in press. Another one has been submitted.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR008079-06
Application #
6282822
Study Section
Project Start
1998-06-15
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

U?urbil, Kamil (2018) Imaging at ultrahigh magnetic fields: History, challenges, and solutions. Neuroimage 168:7-32
Foell, Jens; Palumbo, Isabella M; Yancey, James R et al. (2018) Biobehavioral threat sensitivity and amygdala volume: A twin neuroimaging study. Neuroimage 186:14-21
Magnitsky, Sergey; Pickup, Stephan; Garwood, Michael et al. (2018) Imaging of a high concentration of iron labeled cells with positive contrast in a rat knee. Magn Reson Med :
Lee, Byeong-Yeul; Zhu, Xiao-Hong; Woo, Myung Kyun et al. (2018) Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter-receiver and dynamic B0 shimming. NMR Biomed 31:
Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2018) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med 48:1673-1684
Herzberg, Max P; Hodel, Amanda S; Cowell, Raquel A et al. (2018) Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia 119:262-270
Bolan, Patrick J; Kim, Eunhee; Herman, Benjamin A et al. (2017) MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial. J Magn Reson Imaging 46:290-302
Nelson, Brent G; Bassett, Danielle S; Camchong, Jazmin et al. (2017) Comparison of large-scale human brain functional and anatomical networks in schizophrenia. Neuroimage Clin 15:439-448
Lyzinski, Vince; Fishkind, Donniell E; Fiori, Marcelo et al. (2016) Graph Matching: Relax at Your Own Risk. IEEE Trans Pattern Anal Mach Intell 38:60-73
Ugurbil, Kamil (2016) What is feasible with imaging human brain function and connectivity using functional magnetic resonance imaging. Philos Trans R Soc Lond B Biol Sci 371:

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