Abstract

Concurrent with the experimental demonstrations of fMRI, calculations and experiments evaluating the vascular origin of the BOLD effect were performed by our group. Calculations previously demonstrated that the BOLD phenomenon has two components, one dependent linearly and other quadratically on the main magnetic field magnitude (Bo) arising from macro-and microvasculature, respectively. Consistent with these theoretical and experimental studies, a study we performed in the last funding period demonstrated that the BOLD contrast-to-noise ratio was found to depend on magnetic field strength less than linearly in voxels containing vessels larger than the voxel itself and greater than linearly in voxels containing a mixture of capillaries and veins/venules with diameter less than that of the voxel. The experimental result in this study further demonstrates that a high magnetic field provides improved contrast for fMRI and more emphasis to more specific areas containing small vessels.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR008079-09
Application #
6467507
Study Section
Project Start
2001-07-01
Project End
2002-05-31
Budget Start
Budget End
Support Year
9
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Herzberg, Max P; Hodel, Amanda S; Cowell, Raquel A et al. (2018) Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia 119:262-270
U?urbil, Kamil (2018) Imaging at ultrahigh magnetic fields: History, challenges, and solutions. Neuroimage 168:7-32
Foell, Jens; Palumbo, Isabella M; Yancey, James R et al. (2018) Biobehavioral threat sensitivity and amygdala volume: A twin neuroimaging study. Neuroimage 186:14-21
Magnitsky, Sergey; Pickup, Stephan; Garwood, Michael et al. (2018) Imaging of a high concentration of iron labeled cells with positive contrast in a rat knee. Magn Reson Med :
Lee, Byeong-Yeul; Zhu, Xiao-Hong; Woo, Myung Kyun et al. (2018) Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter-receiver and dynamic B0 shimming. NMR Biomed 31:
Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2018) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med 48:1673-1684
Bolan, Patrick J; Kim, Eunhee; Herman, Benjamin A et al. (2017) MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial. J Magn Reson Imaging 46:290-302
Nelson, Brent G; Bassett, Danielle S; Camchong, Jazmin et al. (2017) Comparison of large-scale human brain functional and anatomical networks in schizophrenia. Neuroimage Clin 15:439-448
Ugurbil, Kamil (2016) What is feasible with imaging human brain function and connectivity using functional magnetic resonance imaging. Philos Trans R Soc Lond B Biol Sci 371:
Musgrove, Donald R; Hughes, John; Eberly, Lynn E (2016) Fast, fully Bayesian spatiotemporal inference for fMRI data. Biostatistics 17:291-303

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