Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
The aim of this project is to develop method based on SWIFT for detection of superparamagnetic iron oxide (SPIO) particle-labeled stem cells in biologically relevant doses in the heart. The preliminary ex- vivo imaging of the heart reveals that SWIFT imaginary images present the off-resonant spins as an enhanced (positive) boundary surrounding the region of SPIO-labeled cells while the on-resonant spins are not visible. SWIFT magnitude images provide myocardium anatomies thus eliminating the need for a separate reference image. Such feature of SWIFT facilitates the detection of stem cells compared to the GRE method.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR008079-19
Application #
8362855
Study Section
Special Emphasis Panel (ZRG1-SBIB-S (40))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
19
Fiscal Year
2011
Total Cost
$30,257
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Herzberg, Max P; Hodel, Amanda S; Cowell, Raquel A et al. (2018) Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia 119:262-270
U?urbil, Kamil (2018) Imaging at ultrahigh magnetic fields: History, challenges, and solutions. Neuroimage 168:7-32
Foell, Jens; Palumbo, Isabella M; Yancey, James R et al. (2018) Biobehavioral threat sensitivity and amygdala volume: A twin neuroimaging study. Neuroimage 186:14-21
Magnitsky, Sergey; Pickup, Stephan; Garwood, Michael et al. (2018) Imaging of a high concentration of iron labeled cells with positive contrast in a rat knee. Magn Reson Med :
Lee, Byeong-Yeul; Zhu, Xiao-Hong; Woo, Myung Kyun et al. (2018) Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter-receiver and dynamic B0 shimming. NMR Biomed 31:
Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2018) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med 48:1673-1684
Bolan, Patrick J; Kim, Eunhee; Herman, Benjamin A et al. (2017) MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial. J Magn Reson Imaging 46:290-302
Nelson, Brent G; Bassett, Danielle S; Camchong, Jazmin et al. (2017) Comparison of large-scale human brain functional and anatomical networks in schizophrenia. Neuroimage Clin 15:439-448
Andronesi, Ovidiu C; Loebel, Franziska; Bogner, Wolfgang et al. (2016) Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate. Clin Cancer Res 22:1632-41
Sun, Yi; Brauckmann, Ole; Nixdorf, Donald R et al. (2016) Imaging human teeth by phosphorus magnetic resonance with nuclear Overhauser enhancement. Sci Rep 6:30756

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