This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We co-organized the SAS 2008 summer school (~50 participants ) with several other beamlines at the APS in July 28 ?August 3. Dr. Liang Guo gave lectures on biological sample preparation, and analysis and modeling of scattering data. Afterwards Drs. Guo and Bekyarova gave hands on training in data analysis to small groups. Six shifts of beamtime were allocated for hands-on experiments by the school participants. Lectures on fiber diffraction and solution scattering were given for the ACA crystallography summer school (Irving, Orgel) which is held at IIT every July. Most on-site training with new user groups is done one-on one by scientific staff. When developing a technique, however, we have found it useful to schedule beamtime in what we call a """"""""workshop"""""""" format where a number of groups, usually a mixture of experienced and inexperienced users share a beamtime allocation where 3-4 groups of users come in for a given 4-6 day period and share the beamtime. Novices will then have the opportunity to observe more experienced users in action and have the opportunity to share experiences with other participants. We have recently adapted this format for scheduling beamtime on the BioCARS 14 BM instrument under the direction of Prof. Orgel. Fourteen IIT students have undergone training in fiber diffraction during this reporting period and at least 15 new students from outside user groups in other modalities. The BioCAT website (www.bio.aps.anl.gov) has a special section on training. A particularly important component is training in safety and compliance issues.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR008630-14
Application #
7954892
Study Section
Special Emphasis Panel (ZRG1-BCMB-E (40))
Project Start
2009-01-01
Project End
2009-12-31
Budget Start
2009-01-01
Budget End
2009-12-31
Support Year
14
Fiscal Year
2009
Total Cost
$84,941
Indirect Cost
Name
Illinois Institute of Technology
Department
Other Basic Sciences
Type
Schools of Arts and Sciences
DUNS #
042084434
City
Chicago
State
IL
Country
United States
Zip Code
60616
Orgel, Joseph P R O; Sella, Ido; Madhurapantula, Rama S et al. (2017) Molecular and ultrastructural studies of a fibrillar collagen from octocoral (Cnidaria). J Exp Biol 220:3327-3335
Yazdi, Aliakbar Khalili; Vezina, Grant C; Shilton, Brian H (2017) An alternate mode of oligomerization for E. coli SecA. Sci Rep 7:11747
Sullivan, Brendan; Robison, Gregory; Pushkar, Yulia et al. (2017) Copper accumulation in rodent brain astrocytes: A species difference. J Trace Elem Med Biol 39:6-13
Morris, Martha Clare (2016) Nutrition and risk of dementia: overview and methodological issues. Ann N Y Acad Sci 1367:31-7
Robison, Gregory; Sullivan, Brendan; Cannon, Jason R et al. (2015) Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation. Metallomics 7:748-55
Gelfand, Paul; Smith, Randy J; Stavitski, Eli et al. (2015) Characterization of Protein Structural Changes in Living Cells Using Time-Lapsed FTIR Imaging. Anal Chem 87:6025-31
Liang, Wenguang G; Ren, Min; Zhao, Fan et al. (2015) Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J Mol Biol 427:1345-1358
Zhou, Hao; Li, Shangyang; Badger, John et al. (2015) Modulation of HIV protease flexibility by the T80N mutation. Proteins 83:1929-39
Baird, Nathan J; Ferré-D'Amaré, Adrian R (2014) Analysis of riboswitch structure and ligand binding using small-angle X-ray scattering (SAXS). Methods Mol Biol 1103:211-25
Nobrega, R Paul; Arora, Karunesh; Kathuria, Sagar V et al. (2014) Modulation of frustration in folding by sequence permutation. Proc Natl Acad Sci U S A 111:10562-7

Showing the most recent 10 out of 100 publications