Abstract

Patients with Alzheimers often complain of an inability to find their way even in familiar surroundings. Many such patients suffer a deterioration of visual function by the loss of acuity, contrast sensitivity, and visual motion sensitivity. We are testing a large, community-based cohort of Alzheimer's patients in an attempt to determine whether their difficulties with spatial orientation might be the result of impaired visual motion processing. Our hypothesis is that focal cortical degeneration in extrastiate visual areas creates a specific incapacity to acces the orienting cues imbedded in the optic flow field.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009283-05
Application #
6122970
Study Section
Project Start
1998-09-23
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Rothkopf, Constantin A; Ballard, Dana H (2013) Modular inverse reinforcement learning for visuomotor behavior. Biol Cybern 107:477-90
Velarde, Carla; Perelstein, Elizabeth; Ressmann, Wendy et al. (2012) Independent deficits of visual word and motion processing in aging and early Alzheimer's disease. J Alzheimers Dis 31:613-21
Fernandez, Roberto; Duffy, Charles J (2012) Early Alzheimer's disease blocks responses to accelerating self-movement. Neurobiol Aging 33:2551-60
Rothkopf, Constantin A; Ballard, Dana H (2010) Credit assignment in multiple goal embodied visuomotor behavior. Front Psychol 1:173
Huxlin, Krystel R; Martin, Tim; Kelly, Kristin et al. (2009) Perceptual relearning of complex visual motion after V1 damage in humans. J Neurosci 29:3981-91
Rothkopf, Constantin A; Ballard, Dana H (2009) Image statistics at the point of gaze during human navigation. Vis Neurosci 26:81-92
Jovancevic-Misic, Jelena; Hayhoe, Mary (2009) Adaptive gaze control in natural environments. J Neurosci 29:6234-8
Kavcic, Voyko; Ni, Hongyan; Zhu, Tong et al. (2008) White matter integrity linked to functional impairments in aging and early Alzheimer's disease. Alzheimers Dement 4:381-9
Droll, Jason A; Hayhoe, Mary M; Triesch, Jochen et al. (2005) Task demands control acquisition and storage of visual information. J Exp Psychol Hum Percept Perform 31:1416-38
Bayliss, Jessica D; Inverso, Samuel A; Tentler, Aleksey (2004) Changing the P300 brain computer interface. Cyberpsychol Behav 7:694-704

Showing the most recent 10 out of 28 publications