The most common application for which probes are requested is that of cortical recording. Although many different cortical areas are being explored (motor, visual, auditory), the preparations share similarities and problems which make collaborations with the Center and between external investigators increasingly important. Along with providing standard probes for acute cortical recording, the Center is working with collaborators (both institutional and corporate) to come up with probes, connectors, chamber designs and preparations for long-term implants. The challenges encountered in most of these preparations include placement of multiple devices into a single cranial chamber; maintaining positional stability of the probes; and inhibition of tissue encapsulation around the cable or 3-D platform due to healing of the cranium and dura. Several of the above collaborators continue to work on cranial chambers designed to hold several integrated cable/probes (either 2-D or 3-D) which protrude from the chamber edge into the cortical area. Some of the fixtures include a removable cap for access to the implants for inspection, cleaning and/or probe replacement. In the area of probe stability, collaborators are working with adhesives such as cyanoacrylate and fibrin glue to anchor the probes to the brain's surface. The University of Michigan Department of Materials Science and Engineering is also developing biological """"""""glues"""""""" as well as materials which will inhibit tissue adhesion to apply to probe substrates. Surgical methods such as tenting of the dura over the probe insertions are being explored as well.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Wallace, M N; Coomber, B; Sumner, C J et al. (2011) Location of cells giving phase-locked responses to pure tones in the primary auditory cortex. Hear Res 274:142-51
Snellings, André; Sagher, Oren; Anderson, David J et al. (2009) Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity. J Neurosurg 111:767-74
Panetsos, Fivos; Avendano, Carlos; Negredo, Pilar et al. (2008) Neural prostheses: electrophysiological and histological evaluation of central nervous system alterations due to long-term implants of sieve electrodes to peripheral nerves in cats. IEEE Trans Neural Syst Rehabil Eng 16:223-32
Lee, Chia-Ming; Chang, Wei-Chih; Chang, Kung-Bo et al. (2007) Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs. Eur J Neurosci 25:2847-61
Maravall, Miguel; Petersen, Rasmus S; Fairhall, Adrienne L et al. (2007) Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex. PLoS Biol 5:e19
Snellings, Andre; Anderson, David J; Aldridge, J Wayne (2006) Improved signal and reduced noise in neural recordings from close-spaced electrode arrays using independent component analysis as a preprocessor. J Neurosci Methods 150:254-64
Ahmed, Bashir; Garcia-Lazaro, Jose A; Schnupp, Jan W H (2006) Response linearity in primary auditory cortex of the ferret. J Physiol 572:763-73
Garcia-Lazaro, J A; Ahmed, Bashir; Schnupp, J W H (2006) Tuning to natural stimulus dynamics in primary auditory cortex. Curr Biol 16:264-71
Leung, L Stan; Peloquin, Pascal (2006) GABA(B) receptors inhibit backpropagating dendritic spikes in hippocampal CA1 pyramidal cells in vivo. Hippocampus 16:388-407
Feng, Zhouyan; Durand, Dominique M (2006) Effects of potassium concentration on firing patterns of low-calcium epileptiform activity in anesthetized rat hippocampus: inducing of persistent spike activity. Epilepsia 47:727-36

Showing the most recent 10 out of 111 publications