Abstract

In addition to the classic probe application areas of cortical, deep structures, peripheral nerve and neural prostheses, there is also interest in using the probes to record from other areas including cardiac muscle and tissue slices. Cardiac muscle, as with peripheral nerve, is a challenging preparation for silicon probes in that penetration is difficult and the relative movement of the structure is very large. Dr. Cascio, in collaboration with Dr. Nagle, has been successful in recording longitudinal activation in an ischemic rabbit papillary muscle. This group has also presented data on activation of the iridium sites to reduce impedances to levels suitable for their recordings. Investigators from several disciplines have been pursuing methods to use probes for recording from tissue slices, including retina and salamandar olfactory bulb.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009754-09
Application #
6660155
Study Section
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
9
Fiscal Year
2002
Total Cost
$200,768
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Wallace, M N; Coomber, B; Sumner, C J et al. (2011) Location of cells giving phase-locked responses to pure tones in the primary auditory cortex. Hear Res 274:142-51
Snellings, André; Sagher, Oren; Anderson, David J et al. (2009) Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity. J Neurosurg 111:767-74
Panetsos, Fivos; Avendano, Carlos; Negredo, Pilar et al. (2008) Neural prostheses: electrophysiological and histological evaluation of central nervous system alterations due to long-term implants of sieve electrodes to peripheral nerves in cats. IEEE Trans Neural Syst Rehabil Eng 16:223-32
Lee, Chia-Ming; Chang, Wei-Chih; Chang, Kung-Bo et al. (2007) Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs. Eur J Neurosci 25:2847-61
Maravall, Miguel; Petersen, Rasmus S; Fairhall, Adrienne L et al. (2007) Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex. PLoS Biol 5:e19
Snellings, Andre; Anderson, David J; Aldridge, J Wayne (2006) Improved signal and reduced noise in neural recordings from close-spaced electrode arrays using independent component analysis as a preprocessor. J Neurosci Methods 150:254-64
Ahmed, Bashir; Garcia-Lazaro, Jose A; Schnupp, Jan W H (2006) Response linearity in primary auditory cortex of the ferret. J Physiol 572:763-73
Garcia-Lazaro, J A; Ahmed, Bashir; Schnupp, J W H (2006) Tuning to natural stimulus dynamics in primary auditory cortex. Curr Biol 16:264-71
Leung, L Stan; Peloquin, Pascal (2006) GABA(B) receptors inhibit backpropagating dendritic spikes in hippocampal CA1 pyramidal cells in vivo. Hippocampus 16:388-407
Feng, Zhouyan; Durand, Dominique M (2006) Effects of potassium concentration on firing patterns of low-calcium epileptiform activity in anesthetized rat hippocampus: inducing of persistent spike activity. Epilepsia 47:727-36

Showing the most recent 10 out of 111 publications