Abstract

Introduction: An analytical method is presented to determine the temporal resolution and dynamic scan duration necessary in the Gd-enhanced dynamic breast MR imaging without compromising the diagnostic efficacy of dynamic images. Methods: The Gd-enhanced signal time curves of various temporal resolutions and scan durations are simulated by manipulating existing patient data. The simulated time curves are fitted by a two-compartment pharmacokinetic model to determine K21 and wash-out slope parameters. The diagnostic efficacy of dynamic images with reduced temporal resolutions and shorter scan durations is tested by ROC analyses of K21 and wash-out slope parameters from simulated time curves. Results: The results suggest that temporal resolution of a few seconds is most desirable and the scan duration is not critical to the diagnostic efficacy of dynamic scan using K21 and wash-out slope if the dynamic scan is long enough to observe the Gd uptake period. However, the fitting for the wash-out slope becomes unstable in short time series. This presents a potential problem in pixel-by-pixel fitting to obtain parametric images using dynamic data of short scans. Conclusions: The analysis presented here can be used to guide researchers in a choice of optimized scan strategy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009784-04
Application #
6282957
Study Section
Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Maclaren, Julian; Aksoy, Murat; Ooi, Melvyn B et al. (2018) Prospective motion correction using coil-mounted cameras: Cross-calibration considerations. Magn Reson Med 79:1911-1921
Guo, Jia; Holdsworth, Samantha J; Fan, Audrey P et al. (2018) Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study. J Magn Reson Imaging 47:1119-1132
Tamir, Jonathan I; Uecker, Martin; Chen, Weitian et al. (2017) T2 shuffling: Sharp, multicontrast, volumetric fast spin-echo imaging. Magn Reson Med 77:180-195
Lai, Lillian M; Cheng, Joseph Y; Alley, Marcus T et al. (2017) Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia. J Magn Reson Imaging 45:1407-1418
Taviani, Valentina; Alley, Marcus T; Banerjee, Suchandrima et al. (2017) High-resolution diffusion-weighted imaging of the breast with multiband 2D radiofrequency pulses and a generalized parallel imaging reconstruction. Magn Reson Med 77:209-220
Uecker, Martin; Lustig, Michael (2017) Estimating absolute-phase maps using ESPIRiT and virtual conjugate coils. Magn Reson Med 77:1201-1207
Kogan, Feliks; Hargreaves, Brian A; Gold, Garry E (2017) Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho. Magn Reson Med 77:1134-1141
Aksoy, Murat; Maclaren, Julian; Bammer, Roland (2017) Prospective motion correction for 3D pseudo-continuous arterial spin labeling using an external optical tracking system. Magn Reson Imaging 39:44-52
Suh, Ga-Young; Choi, Gilwoo; Herfkens, Robert J et al. (2016) Three-Dimensional Modeling Analysis of Visceral Arteries and Kidneys during Respiration. Ann Vasc Surg 34:250-60
Ong, Frank; Lustig, Michael (2016) Beyond Low Rank + Sparse: Multi-scale Low Rank Matrix Decomposition. IEEE J Sel Top Signal Process 10:672-687

Showing the most recent 10 out of 446 publications